Special Issue on Anesthetics & Alzheimer's disease Role:   Guest Editor & Contributor November, 2010	This special Issue will bring latest research on biomarkers for Alzheimer's disease using MRI/MRS/fMRI and PET technology Expected early 2012

Selected (30/37 with pdf) Publications (For All 37 Publication)

(* refers to Corresponding Author)

• Pravat K Mandal*, Manjari Tripathi and Sreedevi Sugunan "Brain oxidative stress: Detection and mapping of anti-oxidant marker ‘Glutathione’ in different brain regions of healthy male/female, MCI and Alzheimer patients using non-invasive magnetic resonance spectroscopy" Biochemical Biophysical Research Communications (2011, in PRESS)



• Pravat K Mandal* "Proton Magnetic Resonance Spectroscopic Signal Processing for the Quantitation of Neurometabolites" European Journal of Radiology (2011)



• Pravat K Mandal* and Himanshu Akolkar " A new experimental approach and signal processing scheme for the detection and quantitation of 31P brain neurochemicals from in vivo MRS studies" Biochemical and Biophysical Research communications, Vol 412, Pages 302-306 (2011)



• Pravat K Mandal* and Vinenzo Fodale " Anesthetics and Alzheimer Disease " Editorial, Journal of Alzheimer Disease, 22, 135-137 (2010)



• Pravat K Mandal* and Manisha Ahuja "Comprehensive Magnetic Resonance Spectroscopic Studies on Interactions of Abeta with Different Molecular Sized Anesthetics" Journal of Alzheimer Disease, 22, 27-34 (2010)



• Fodale, Vinenzo; Ritchie, Karen; Rasmussen, Lars ; and Pravat K Mandal* (2010). "Anesthetics and Alzheimer's Disease: Background and Research" J Alzheimer Disease, 22, 1-3 (2010)
  
  
• Daniela Schifilliti, Letterio B. Santamaria, Giovanni Rosa, Gianfranco Di Nino,
  Pravat K. Mandal, and Vincenzo Fodale "Cholinergic Central System, Alzheimer’s Disease and Anesthetics Liaisons: a vicious circle?" Journal of Alzheimer Disease, 22, 35-41 (2010).
  
  
  
• Pravat K Mandal*, Neel S Bhavesh, Virender S. Chauhan and Vincenzo Fodale  "NMR investigations of Aβ peptide interactions with propofol at clinically relevant concentrations with and without aqueous halothane solution" Journal of Alzheimer Disease, (21:1303-1309, 2010) 
  
  
• Pravat K Mandal^*, Virgil Simplaceanu  and Vincenzo Fodale : "Intravenous Anesthetic Diazepam does not induce Amyloid beta-peptide Oligomerization but Diazepam Co-administered with Halothane Oligomerizes Amyloid Beta-peptide: An NMR study"  Journal of Alzheimer Disease (Vol 20(1) pages 127-134, 2010) 
  
  
• V. Fodale, L.B. Santamaria, D. Schifilliti and P. K. Mandal : "Anaesthetics and post-operative cognitive dysfunction: a pathological mechanism mimicking Alzheimer’s Disease" Anesthesia Journal (Vol 65(4) page 388-395, April 2010).
  
  
• Pravat K. Mandal^* and Vincenzo Fodale :" Smaller molecular-sized anaesthetics oligomerize Abeta peptide simulating Alzheimer’s disease: a relevant issue"
  European Journal of Anesthesiology, Vol 26(10) Page 805-806 , 2009 - Editorial
  
  
• Pravat K. Mandal^*, Daniela Schifilliti, Federica Mafrica, and Vincenzo Fodale "Inhaled Anesthetics and Cognitive Performance" Drugs of Today, (45: 47-54, 2009).
  
  
• Pravat K Mandal^*, Vincenzo Fodale "Isoflurane and desflurane at clinically relevant concentrations induce amyloid beta-peptide oligomerization: An NMR study" Biochemical and Biophysical Research Communications. (379: 716-720, 2009)
  
  
• Pravat K. Mandal^*, J. W. Pettegrew,” Abeta Peptide interactions with Isoflurane, Propofol, Thiopental and combined Thiopental with Halothane: A NMR  Study” Biochemica Biophysica Acta, Biomembrane, (1778: 2633-2639 , 2008).
  
  
• Pravat K. Mandal^*, J. W. Pettegrew,” Clinically relevant concentration determination of inhaled anesthetics (halothane, soflurane, sevoflurane and desflurane) by 19F NMR” Cell Biochemistry and Biophysics, (52:31-35, 2008)
  
  
• Pravat K Mandal^*, “Magnetic Resonance Spectroscopy (MRS) and its application in Alzheimer’s Disease”  Concepts in Magnetic Resonance Part A (30, 40-65, 2007).
  
  
• Pravat K. Mandal^*, J. W. Pettegrew, E. Masliah,., R. L. Hamilton, and R. Mandal “Interaction between Aβ Peptide and α Synuclein: Molecular Mechanisms in Overlapping Pathology of Alzheimer’s and Parkinson’s in Dementia with Lewy Body disease” Neurochemical Research, 31,1153-1162, (2006)
  
  
• Pravat K. Mandal^* and A. Majumdar, “A Comprehensive Discussion of HMQC and HSQC Pulse Sequences ” Concepts In Magnetic Resonance, 20A, 1-23 (2004).
  
  
• Pravat K. Mandal and Jay W. Pettegrew, “Alzheimer Disease: NMR studies of AsialoGM1 and trisialo (GT1b) ganglioside interactions with Ab(1-40) peptide in Membrane mimic environment” Neurochemical. Research, 29, 447-453 (2004).
  
  
• Pravat K. Mandal, R. McClure, J. W. Pettegrew “Interactions of Ab;(1-40)  with Glycerophosphocholine and Intact Erythrocyte Membranes: Fluorescence and Circular Dichroism Studies” (Neurochemical Research, 29, 2273-2279, 2004)
  
  
• Pravat K. Mandal,  Pettegrew JW  “Alzheimer’s disease: soluble oligomeric Aβ(1.40) peptide in membrane mimic  environment from solution NMR and circular dichroism studies” (Neurochemical Research, 29, 2267-2272, 2004)
  
  
• Pravat K. Mandal^*, “Complete NMR Spectroscopic Assignment of a Neuronal Transduction Protein” Monatshefte  fur Chemie, 133,205-217 (2002).
  
  
• Pravat K. Mandal, P. K. Madhu and N. Muller, “Nuclear Magnetic Relaxation of Methyl Protons in a Paramagnetic Protein: Cross-correlation Effects” Chemical Physics Letters, 320, 269-276 (2000).
  
  
• H. Tochio, Q. Zhang, Pravat K. Mandal, M. Li and M. Zhang, “Solution Structure of the Extended Neuronal Nitric Oxide Synthase PDZ Domain Complexed with an Associated Peptide” Nature Structural Biology, 6, 417-421 (1999).
  
  
• de Ropp, Pravat K. Mandal, GN Lamar, “Solution 1H NMR Investigation of the Heme Cavity and Substrate Binding site of Cyanine-Inhibited Horseradish peroxidase” Biochemistry, 38, 1077-1086 (1999).
  
  
• de Ropp, Pravat K. Mandal, S. Braur and GN Lamar, “Solution NMR Study of the Electronic and Molecular Structure of Heme Cavity in High Spin Resting State Horseradish Peroxidase” Journal of American Chemical Society, 119, 4732-4739 (1997).
  
  
• Pravat K. Mandal, B. Sinha, P. T. Manoharan and R. Ramasesha, “Diagrammetic Valence Bond Studies on Hemocyanin” Theoretica Chemica Acta, 93, 1-16 (1996).
  
  
• Pravat K. Mandal and P. T. Manoharan, “A Comprehensive Study of Exchange Coupling in a Macrocyclic Binuclear Copper (II) Complex in a Solid and Solution States” Inorganic Chemistry, 34, 270-277 (1995).
  
  
• Pravat K. Mandal and P. T. Manoharan, “Effect of Fifth Coordination Site on the Spin States of Bis (Benzoylacetylacetanato) Bis pyridine dicopper (II) Complex” Chemical Physics Letters, 210, 463-470 (1993).
  
  
• Pravat K. Mandal, B. Sinha, P. T. Manoharan and S. Ramasesha, “Theoretical Studies of Spin States of Macrocyclic Aza-amido Binuclear Copper (II) Complexes ” Chemical Physics Letters, 191, 448-454 (1992).

Ongoing Financial Support

Previous Research Funding from different National Agencies (USA)